Evidence Based Digoxin Therapeutic Monitoring - A Lower and Narrower Therapeutic Range

A Computer-based Pharmacokinetic Implementation for Digoxin Therapeutic Monitoring in Pediatric Patients

ABTRACT Because of the narrow therapeutic range and large inter-patient variability in digoxin’s pharmacokinetics and pharmacodynamics, an appropriate dosage regimen for individuals is needed. However, monitoring and adjusting the optimal individualized dosage regimen requires a knowledge and familiarity of pharmacokinetic equations. The objective of this study was to develop a computer-based p...

A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs

Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...

Evidence-based implementation of free phenytoin therapeutic drug monitoring.

BACKGROUND The majority of laboratories measure total phenytoin concentration for therapeutic drug monitoring. However, there are substantial interindividual variations in free phenytoin concentrations, the pharmacologically active component. METHODS We describe the process and data used to implement monitoring of free phenytoin only in an urban medical center. Over a 6-week period, total and...

monitoring cyclosporine absorption: a step beyond therapeutic drug monitoring

therapeutic drug monitoring

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